Robin Williams - Early Signs Of Parkinsons's related Dementia At Death - Prescribed Black Box Warning Antipsychotic Seroquel

Robin Williams - Showed Early Signs Of Parkinsons's related Dementia At Death - Prescribed Black Box Warning Anti-psychotic Seroquel

 radaronline.com/exclusives/2014/11/robin-williams-coroners-report-death-suicide/

information for SEROQUEL.

SEROQUEL®

(quetiapine fumarate) Tablets

Initial US Approval: 1997

WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS

WITH DEMENTIA-RELATED PSYCHOSIS

 •Antipsychotic drugs are associated with an increased risk of death (5.1)

• Quetiapine is not approved for elderly patients with Dementia-Related Psychosis (5.1)

WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS

See Full Prescribing Information for complete boxed warning.

• Increased risk of suicidal thinking and behavior in children, adolescents and young adults taking antidepressants for major depressive disorder and other psychiatric disorders

Alert for Healthcare Professionals: Quetiapine (marketed as Seroquel)

9/2006: The issue described in this alert has been addressed in product labeling.

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FDA Alert [4/11/2005]: Increased Mortality in Patients with Dementia-Related Psychosis

FDA has determined that patients with dementia-related psychosis treated with atypical (second generation) antipsychotic medications are at an increased risk of death compared to placebo. Based on currently available data, FDA has requested that the package insert for Seoquel be revised to include a black box warning describing this risk and noting that this drug is not approved for this indication.

 fda/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders

 science_news/release/seroquel

 parkinson-s-patients-still prescribed-antipsychotics-despite-warning-

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WebMD parkinsons-disease/antipsychotics-used-for-parkinsons-despite-warnings

Doctors continue to prescribe antipsychotic drugs to their patients with Parkinson's disease and psychosis, despite "black box" warnings from the FDA linking them to increased risk of death among patients with dementia, a study shows.

A black box warning is the strongest drug warning issued by the FDA.

"My sense is that the black box warnings don't factor into decision making," says study researcher Daniel Weintraub, MD, an associate professor of psychiatry at the University of Pennsylvania.

The study is published in the Archives of Neurology.

The black box warning for antipsychotics says the drugs are associated with an increased risk of death for those with dementia, which is common among people diagnosed with Parkinson's. Some commonly prescribed antipsychotics also worsen symptoms of Parkinson's.

ENOUGH SAID!