Sunday, November 9, 2014

Robin Williams - Early Signs Of Parkinsons's related Dementia At Death - Prescribed Black Box Warning Antipsychotic Seroquel

Robin Williams - Showed Early Signs Of Parkinsons's related Dementia At Death - Prescribed Black Box Warning Anti-psychotic Seroquel

 radaronline.com/exclusives/2014/11/robin-williams-coroners-report-death-suicide/



information for SEROQUEL.
SEROQUEL®
(quetiapine fumarate) Tablets
Initial US Approval: 1997

WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS
WITH DEMENTIA-RELATED PSYCHOSIS
 Antipsychotic drugs are associated with an increased risk of death (5.1)
Quetiapine is not approved for elderly patients with Dementia-Related Psychosis (5.1)

WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS
See Full Prescribing Information for complete boxed warning.
Increased risk of suicidal thinking and behavior in children, adolescents and young adults taking antidepressants for major depressive disorder and other psychiatric disorders


Alert for Healthcare Professionals: Quetiapine (marketed as Seroquel)

9/2006: The issue described in this alert has been addressed in product labeling.

FDA Alert [4/11/2005]: Increased Mortality in Patients with Dementia-Related Psychosis
FDA has determined that patients with dementia-related psychosis treated with atypical (second generation) antipsychotic medications are at an increased risk of death compared to placebo. Based on currently available data, FDA has requested that the package insert for Seoquel be revised to include a black box warning describing this risk and noting that this drug is not approved for this indication.


 science_news/release/seroquel

 parkinson-s-patients-still prescribed-antipsychotics-despite-warning-

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WebMD parkinsons-disease/antipsychotics-used-for-parkinsons-despite-warnings

Doctors continue to prescribe antipsychotic drugs to their patients with Parkinson's disease and psychosis, despite "black box" warnings from the FDA linking them to increased risk of death among patients with dementia, a study shows.

A black box warning is the strongest drug warning issued by the FDA.

"My sense is that the black box warnings don't factor into decision making," says study researcher Daniel Weintraub, MD, an associate professor of psychiatry at the University of Pennsylvania.
The study is published in the Archives of Neurology.

The black box warning for antipsychotics says the drugs are associated with an increased risk of death for those with dementia, which is common among people diagnosed with Parkinson's. Some commonly prescribed antipsychotics also worsen symptoms of Parkinson's.

ENOUGH SAID!

Friday, October 10, 2014

Texas AG opens lawsuit against AstraZeneca for the illegal marketing of Seroquel

Texas AG opens lawsuit against AstraZeneca for criminal fraud and the illegal marketing of Seroquel



Not that this news will have much of an effect on this politically connected corporate giant, or will it bring any solace to the countless thousands of lives lost, ruined, and cask aside by this criminal corporation.

Those that have followed the Pharmaceutical corporate crime wave over the past couple of decades are asking the following question once again: What "CIA" Corporate Integrity Agreement?

This litigation has all the makings of just another chump change settlement where AstraZeneca pays a small fine and admits no wrong doing. It's just the way in works today in the United States of America. AZ is to big and connected to be held accountable...AstraZeneca is after all a member of the elite ruling class CLUB, and you the average Joe/Jane citizen are not invited to their club house party.

The Wall Street Journal, veteran and well respected reporter Ed Silverman of Pharmalot fame are reporting:

Texas AG Lawsuit Claims AstraZeneca Improperly Marketed Seroquel

The Texas Attorney General has filed a lawsuit this week against AstraZeneca that alleges the drug maker illegally marketed its Seroquel antipsychotic pill for unapproved uses, paid kickbacks to physician and state health officials, and subsequently caused the state Medicaid program to overpay for the medicine.

The lawsuit, which was filed in a state court in Texas, builds on claims in lawsuits that were filed by two former AstraZeneca sales reps, who alleged the drug maker used various tactics to induce physicians to prescribe different versions of the Seroquel pill.
As an example, the drug maker allegedly paid $465,000 to a pair of unidentified state mental health officials “with the power to influence formulary decisions within the state hospital system,” according to the lawsuit. A formulary is listed of drugs for which an insurer offers reimbursement.

To read the complete article:  wsj.com/pharmalot/texas-ag-lawsuit-claims-astrazeneca-improperly-marketed-seroquel/

Related Links:
 fiercepharma.com/story/texas-ag-astrazeneca-paid-465k-kickbacks-committed-fraud-seroquel-marketing

biopharmadive.com/news/az-faces-texas-lawsuit-over-bribery-improper-marketing-of-antipsychotic

Friday, November 1, 2013

AstraZeneca Seroquel - The criminal cover-up that is still killing decades later - a walk down tragedy's memory lane


After all the propaganda and empty promises...From the White House, The Senate, The Congress, The Federal Courts, The DOJ, The FDA, A Billion Dollar AstraZeneca Legal Dream Team, and finally all those seedy plaintiff law firms who sold out their own clients for huge profits; No one has been held accountable for these unconscionable crimes that have either killed or severely injured many many thousands of innocent victims.

This blog has chronicled this dead-end journey from the injured parties' perspective, attempting to tell the story that is seldom reported by the news media, in the faint hope that some day justice will be served, and that these kinds of corporate criminal tragedies are not repeated in the future.

 Unfortunately, that is just not reality...the entrenched greed and corruption continues to prevail at every turn and all levels of the regulatory and judicial process. These pages have been read by all of the aforementioned parties highlighted above to no avail. This blog has been attacked, faced numerous threats/acts of intimidation for exposing and reporting the truth. Unfortunately, the only success that has been accomplished is public awareness and a living archive of what everyday citizens face when confronting institutionalized corruption.

Today, I would like to share once more an excellent program produced by BBC News years ago...nothing has really changed since this report; yet I believe it encapsulates this criminal story as well as any report to date.  I ask you to take a walk down this tragic memory lane and never forget...it was very real people just like yourself that had their lives and health destroyed simply in the name of unquenchable corporate greed. I believe you will find the time spent listening to this broadcast well worth the time invested.

Drug danger distraction?

Duration: 40 minutes
First broadcast: Tuesday 26 January 2010
A British drug company is being sued by more than 15,000 people in the United States who claim its bestselling antipsychotic drug caused severe weight gain, diabetes and other serious medical conditions. Ann Alexander investigates concerns about the way it was marketed and asks how much the public should be told about the drugs they take.

http://www.bbc.co.uk/programmes/b00q3gjj

Saturday, July 27, 2013

AstraZeneca, GSK, and The Pharmaceutical Industry Crime Syndicate - Criminal Bribery, Sex, Drugs, & Fun Times in China...


                                      Hat Tip to pharmagossip for (edited) image
                          
AstraZeneca, GSK, and The Pharmaceutical Industry Crime Syndicate - Criminal Bribery, Sex, Drugs, & Fun Times in China...

As if the latest information and news comes as any surprise to anyone with these TOO BIG TO FAIL, TOO BIG TO BE HELD ACCOUNTABLE pharmaceutical corporate giants...remember all those CIA's (corporate integrity agreements), the meaningless token fines, the ghost writing, the hidden information, crimes, and lawsuits...the shallow apologies...When it comes to money & profits it all means absolutely nothing...read & weep as you peruse the following articles...


"Police also detained two members of AstraZeneca's Chinese staff for questioning on Tuesday. The employees in Astra's main Shanghai sales centre are line managers of an Astra sales representative detained on Friday.
An Astra spokeswoman said one of the managers was "continuing to assist the [Shanghai public security] bureau with their inquiries". She said there was "no reason to believe [the arrest] is related to other investigations".
Meanwhile, four more western drug companies – Sanofi, Novartis, Merck and Roche – said they had used the same travel agency that GSK allegedly used to funnel bribes to doctors. All four companies said they had stopped using the Shanghai Linjiang agency."


 "The woman, named as Ms Wang, said “some executives gave clear directives to the sales department to offer bribes to doctors with money or opportunities to attend academic conferences.”
Ms Wang said she would even go so far as fulfilling some doctors’ “sexual desires” in order to “meet their needs” and persuade them to prescribe more drugs.
A doctor from a “reputable hospital” whose real name was not given, claimed that one GSK representative had “blatantly offered kickbacks to doctors”. 

And at The 1 Boring Old Man Blog the conversation is already getting hot hot hot with new post an-irreducible-conflict and more-china

"The industry thrives by relying on irrational exuberance, well designed illusion, and a dash or two of crime. And they can’t seem to stop…"

Also, over at Pharmalot  bribes-sex-fraud-did-glaxo-violate-its-corporate-integrity-agreement

 "A violation could lead the US Department of Health and Human Services Office of Inspector General to seek to exclude the drugmaker from contracts with federal healthcare programs, such as Medicare and Medicaid. This is big business, of course, and so any whiff of trouble that could impact the CIA has investors on alert.

On a conference call this morning to discuss the latest earnings, Glaxo ceo Andrew Witty was asked whether Glaxo staff believe the scandals in China would have an effect on the CIA, since it is known that US authorities are probing the drugmaker for violations of the Foreign Corrupt Practices Act (this is the law) and the UK's Serious Fraud Office is also conducting a probe. Witty, however, breezed past the question without offering a response."

 Some back story here --> astrazeneca-seroquel-marketing 


                                                      Image via the world renowned PharmaGiles


Friday, August 24, 2012

South Carolina Attorney General reaches $26M settlement against AstraZeneca for "willfully misleading consumers on the potentially serious side effects of the anti-psychotic drug Seroquel"


SC Attorney General reaches $26M settlement against AstraZeneca

Published: Thursday, August 23, 2012 at 5:46 p.m.
Last Modified: Thursday, August 23, 2012 at 5:46 p.m.
The S.C. Attorney General's Office has secured a $26 million settlement against the multi-billion pharmaceutical company AstraZeneca for violating the state Unfair Trade Practices Act by willfully misleading consumers on the potentially serious side effects of the anti-psychotic drug Seroquel.
The settlement order was filed Aug. 22 and is the third award, and final case against anti-psychotic drug manufacturers in South Carolina, that the Attorney General's Office has prosecuted since 2009. The cases began under former Attorney General Henry McMaster, who contracted with the Spartanburg law firm of Harrison, White, Smith and Coggins to prosecute the case on behalf of the state. The Spartanburg firm then contracted with two other firms in Columbia and Houston to assist with the litigation, which continued under Attorney General Alan Wilson.
In the lawsuit order, the company agreed to pay $26 million, which includes $20 million in damages and restitution to the state, $5 million in penalties and $1 million in trial costs. In 2010, AstraZeneca had $5.3 billion in worldwide sales including $3.75 billion in the U.S.
Bryan Stirling, deputy attorney general, said the settlement is fair to the state. A portion of the funds will go into the general fund, some will go to Medicaid and other funds to insurance companies.
Stirling said the Attorney General's Office sued on behalf of the state and the state agencies that paid additional funds because of the medication side effects.
AstraZeneca did not admit any wrongdoing or violation, but agreed to pay the sum to resolve the state action, according to the order signed by Circuit Court Judge Roger Couch."