Sunday, November 9, 2014

Robin Williams - Early Signs Of Parkinsons's related Dementia At Death - Prescribed Black Box Warning Antipsychotic Seroquel

Robin Williams - Showed Early Signs Of Parkinsons's related Dementia At Death - Prescribed Black Box Warning Anti-psychotic Seroquel

information for SEROQUEL.
(quetiapine fumarate) Tablets
Initial US Approval: 1997

 Antipsychotic drugs are associated with an increased risk of death (5.1)
Quetiapine is not approved for elderly patients with Dementia-Related Psychosis (5.1)

See Full Prescribing Information for complete boxed warning.
Increased risk of suicidal thinking and behavior in children, adolescents and young adults taking antidepressants for major depressive disorder and other psychiatric disorders

Alert for Healthcare Professionals: Quetiapine (marketed as Seroquel)

9/2006: The issue described in this alert has been addressed in product labeling.

FDA Alert [4/11/2005]: Increased Mortality in Patients with Dementia-Related Psychosis
FDA has determined that patients with dementia-related psychosis treated with atypical (second generation) antipsychotic medications are at an increased risk of death compared to placebo. Based on currently available data, FDA has requested that the package insert for Seoquel be revised to include a black box warning describing this risk and noting that this drug is not approved for this indication.


 parkinson-s-patients-still prescribed-antipsychotics-despite-warning-



WebMD parkinsons-disease/antipsychotics-used-for-parkinsons-despite-warnings

Doctors continue to prescribe antipsychotic drugs to their patients with Parkinson's disease and psychosis, despite "black box" warnings from the FDA linking them to increased risk of death among patients with dementia, a study shows.

A black box warning is the strongest drug warning issued by the FDA.

"My sense is that the black box warnings don't factor into decision making," says study researcher Daniel Weintraub, MD, an associate professor of psychiatry at the University of Pennsylvania.
The study is published in the Archives of Neurology.

The black box warning for antipsychotics says the drugs are associated with an increased risk of death for those with dementia, which is common among people diagnosed with Parkinson's. Some commonly prescribed antipsychotics also worsen symptoms of Parkinson's.


Friday, October 10, 2014

Texas AG opens lawsuit against AstraZeneca for the illegal marketing of Seroquel

Texas AG opens lawsuit against AstraZeneca for criminal fraud and the illegal marketing of Seroquel

Not that this news will have much of an effect on this politically connected corporate giant, or will it bring any solace to the countless thousands of lives lost, ruined, and cask aside by this criminal corporation.

Those that have followed the Pharmaceutical corporate crime wave over the past couple of decades are asking the following question once again: What "CIA" Corporate Integrity Agreement?

This litigation has all the makings of just another chump change settlement where AstraZeneca pays a small fine and admits no wrong doing. It's just the way in works today in the United States of America. AZ is to big and connected to be held accountable...AstraZeneca is after all a member of the elite ruling class CLUB, and you the average Joe/Jane citizen are not invited to their club house party.

The Wall Street Journal, veteran and well respected reporter Ed Silverman of Pharmalot fame are reporting:

Texas AG Lawsuit Claims AstraZeneca Improperly Marketed Seroquel

The Texas Attorney General has filed a lawsuit this week against AstraZeneca that alleges the drug maker illegally marketed its Seroquel antipsychotic pill for unapproved uses, paid kickbacks to physician and state health officials, and subsequently caused the state Medicaid program to overpay for the medicine.

The lawsuit, which was filed in a state court in Texas, builds on claims in lawsuits that were filed by two former AstraZeneca sales reps, who alleged the drug maker used various tactics to induce physicians to prescribe different versions of the Seroquel pill.
As an example, the drug maker allegedly paid $465,000 to a pair of unidentified state mental health officials “with the power to influence formulary decisions within the state hospital system,” according to the lawsuit. A formulary is listed of drugs for which an insurer offers reimbursement.

To read the complete article:

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